#Please insert up references in the next lines (line starts with keyword UP) UP arb.hlp UP glossary.hlp #SUB subtopic.hlp TITLE Optimize database compression OCCURRENCE ARB_NT DESCRIPTION Sequence data normally need's a lot of memory. To be able to handle thousands of sequences we implemented an online compression. All data is compressed most of the time and only uncompressed on demand. As a user you only find smaller database files, that's all. Without understanding the data, the program can compress data only by a limited factor. With the help of a tree aligned sequences can be compressed much better by storing only the differences to a consensus sequence. Once a sequence is compressed using a tree, it will keep the good compression method until it is changed. Then only the older method is used. As long as you change only a few (up to 100) sequences, the database won't grow very much. To compress the entire database, the program needs a tree, which should cover most of the sequences. The larger and better the tree, the better the compression. EXAMPLE 10000 aligned 16s sequences need 50 mega-bytes of memory. Without your help ARB will reduce them to 10 mega-bytes, and given a tree not more than 2 mega-bytes will be needed. NOTES Any major database update, especially inserting or deleting gaps in an alignment, should be followed by a new optimization step. BUGS No bugs known